A Journey from Frustration to Self Management

Dysregulation Spectrum Syndrome

Dr. Muhammad Yunus


Dysregulation Spectrum Syndrome (DSS) as defined by Dr. Yunus views fibromyalgia symptoms and chronic fatigue syndrome as being a part of a larger Spectrum of conditions, which he calls Dysregulation Spectrum Syndrome commonly referred to as DSS.

Most patients with chronic pain share more than one of these syndromes.  

He defines dysregulation as bio-physiological abnormalities, possibly in the neurological, hormonal and chemical systems which lead to negative immune system responses.

Dysregulation Syndromes (like fibromyalgia) run together.  For those that suffer from them, life is more than “impaired”.  It can be life altering and miserable.

Characteristics of the Dysregulation Spectrum Syndrome

1. Clustering of DSS members (IBS, Migraines, MPS, CFS, etc) in a given patient group. These symptoms occur   more often than in the general population

2. A sharing of clinical characteristics among patients

3. A generalized hyperalgesic (increased sensitivity to pain) state

4. Absence of the “classical Disease Model”.  By this he means NO injury or illness can be identified by clinical signs, lab test, X-rays, etc and conventional treatment can be expected to work to effect a cure or relief.

5. Absence of the typical Psychiatric Model

6. A common Neuroendocrine mechanism (biophysiology as opposed to pathophysiology)

7. A Common genetic linkage

8. Responsive to neuromodulating drugs or Interventions

IBS, headaches, and dysmenorrhea occur in fibromyalgia more commonly than in the general population. This occurrence is far greater than it would be by chance.

Restless Leg Syndrome (RLS) occurs in 31% of people with Fibromyalgia, 15% of people with Rheumatoid Arthritis, and only 2% in the general population.

Fibromyalgia occurs in 33% of people diagnosed with Rheumatoid Arthritis.

IBS is more common in fibro patients.  This is not true of patients with Inflammatory Bowel Disease such as Chron’s or Ulcerated Colitis.

Dysregulation Spectrum Syndrome (DSS)

Family of Syndromes and Over-lapping Conditions

Dysregulation Spectrum Syndrome

Dysregulation Spectrum Syndrome

1. Fibromyalgia Syndrome (FMS)

2. Chronic Fatigue Syndrome (CFS)

3. Myofascia Pain Syndrome (MPS)

4. Restless Leg Syndrome (RLS)

5. Irritable Bowel Syndrome (IBS)

6. Irritable Bladder Syndrome (IBBS)

7. Primary Dysmenorrhea

8. Migraine Headaches

9. Tension Headaches

10. Temporal Mandibular Joint Disease (TMJD)

11. Multiple Chemical Sensitivity (MCS)

12. Periodic Leg Movement in Sleep (PLMS)